Dr Peña's clinical and research interests' include the treatment for Barrett's esophagus and early esophageal cancer using endoscopic mucosal resection (EMR) and mucosal ablation including radiofrequency ablation and cryoablation; endoscopic retrograde cholangiopancreatography (ERCP) for biliary and pancreatic disorders including cancer, esophageal stenting and wireless capsule endoscopy for small bowel evaluation. Additional research interests include endoscopic outcomes and capsule endoscopy.